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Are there clinical trials for MOTS-c?
MOTS-c has only 5 registered clinical trials, reaching Phase 2, with 0 completed. That is early-stage evidence: it is not established clinical evidence of effectiveness in humans.
Trial breakdown
By phase
| Phase 2 | 1 |
| Not applicable | 1 |
By status
| Recruiting | 3 |
| Active, not recruiting | 1 |
| Unknown status | 1 |
Active trials
- Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal TransplantationNot applicable · Recruiting · 68 participants · University of Gaziantep · started 2026-03-01NCT07678073
- MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/ObesityPhase 2 · Recruiting · 120 participants · Hudson Biotech · started 2026-02-02NCT07505745
- The Cardiovascular Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their CombinationRecruiting · 240 participants · University of Athens · started 2017-11-03NCT03878706
- Cohort Of DEafness-gene ScreeningActive, not recruiting · 35920 participants · Affiliated Hospital of Nantong University · started 2016-01-01NCT06133946
Most recent registered trials
- Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal TransplantationNot applicable · Recruiting · 68 participants · University of Gaziantep · started 2026-03-01NCT07678073
- MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/ObesityPhase 2 · Recruiting · 120 participants · Hudson Biotech · started 2026-02-02NCT07505745
- The Cardiovascular Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their CombinationRecruiting · 240 participants · University of Athens · started 2017-11-03NCT03878706
- Cohort Of DEafness-gene ScreeningActive, not recruiting · 35920 participants · Affiliated Hospital of Nantong University · started 2016-01-01NCT06133946
- Platelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CADUnknown status · 120 participants · University of Athens · started 2014-01-01NCT04027712
Frequently asked questions
Are there clinical trials for MOTS-c?
MOTS-c has only 5 registered clinical trials, reaching Phase 2, with 0 completed. That is early-stage evidence: it is not established clinical evidence of effectiveness in humans.
Does a registered trial mean the peptide works?
No. Registration means a study was formally listed before or during the research. It says nothing about the result. A completed trial can find no benefit, and many registered studies are never published.
What is the difference between a registered trial and published evidence?
Registration records that a study exists. Publication reports what it found. This page counts registrations, which is the more complete picture of research activity, but it is not a measure of proven effectiveness.
Why do phases matter?
Phase 1 tests safety in a small group. Phase 2 looks for early signs of effect. Phase 3 tests effectiveness against a comparator in a large group, and is what regulators normally require. Phase 4 studies happen after approval. A compound with only Phase 1 trials has not been shown to work.
Source: ClinicalTrials.gov API v2, U.S. National Library of Medicine. Studies where MOTS-c is registered as an intervention. Last updated 2026-09-23.