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Are there clinical trials for Kisspeptin?
Kisspeptin has 36 registered clinical trials, including 15 completed interventional studies and trials reaching Phase 3. Its use in humans is supported by established registered clinical evidence.
Trial breakdown
By phase
| Phase 1 | 12 |
| Phase 2 | 8 |
| Not applicable | 3 |
| Phase 3 | 3 |
By status
| Completed | 23 |
| Recruiting | 5 |
| Terminated | 4 |
| Withdrawn | 2 |
| Unknown status | 2 |
Active trials
- Kisspeptin to Quantify GnRH Neuronal Function in Health and DiseasePhase 1 · Recruiting · 40 participants · Stephanie B. Seminara, MD · started 2026-03-10NCT07224490
- Kisspeptin Administration Subcutaneously to Patients With Hypothalamic AmenorrheaPhase 2 · Recruiting · 20 participants · Stephanie B. Seminara, MD · started 2025-12-09NCT07224438
- Functional Proteins in Polycystic Ovary SyndromeRecruiting · 100 participants · Jagiellonian University · started 2025-01-20NCT06793098
- Kisspeptin Administration Subcutaneously to Patients With IHHPhase 2 · Recruiting · 36 participants · Stephanie B. Seminara, MD · started 2023-02-03NCT05896293
- Reproductive Hormones During Sustained Administration of KisspeptinNot applicable · Recruiting · 76 participants · Imperial College London · started 2014-04-02NCT02081924
Most recent registered trials
- Kisspeptin to Quantify GnRH Neuronal Function in Health and DiseasePhase 1 · Recruiting · 40 participants · Stephanie B. Seminara, MD · started 2026-03-10NCT07224490
- Kisspeptin Administration Subcutaneously to Patients With Hypothalamic AmenorrheaPhase 2 · Recruiting · 20 participants · Stephanie B. Seminara, MD · started 2025-12-09NCT07224438
- Functional Proteins in Polycystic Ovary SyndromeRecruiting · 100 participants · Jagiellonian University · started 2025-01-20NCT06793098
- Kissing as a Protective Factor Against Acidic pH in SalivaNot applicable · Completed · 33 participants · Universidad Catolica Santiago de Guayaquil · started 2024-07-30NCT06501729
- A Prospective Cohort Study on the Serum Kisspeptin Levels Throughout Pregnancy in PCOSUnknown status · 180 participants · Fudan University · started 2024-06-28NCT06545994
- Recall by Genotype: Neuropeptide StimulationPhase 1 · Terminated · 16 participants · Stephanie B. Seminara, MD · started 2023-10-20NCT05901467
- Dampening the Reproductive Axis With Continuous KisspeptinPhase 1 · Completed · 8 participants · Stephanie B. Seminara, MD · started 2023-10-06NCT05971849
- Evaluation of Some Puberty-related Hormones Among Children and Adolescents With Chronic Kidney DiseasesUnknown status · 50 participants · Sohag University · started 2023-05NCT05835089
- Kisspeptin Administration Subcutaneously to Patients With IHHPhase 2 · Recruiting · 36 participants · Stephanie B. Seminara, MD · started 2023-02-03NCT05896293
- Kisspeptin Administration Subcutaneously to Patients With Reproductive DisordersPhase 1 · Completed · 13 participants · Stephanie B. Seminara, MD · started 2022-12-16NCT05633966
- Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic ClampPhase 1 · Withdrawn · Massachusetts General Hospital · started 2022-06-03NCT05456854
- Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Oral Glucose Tolerance TestPhase 1 · Completed · 16 participants · Massachusetts General Hospital · started 2021-10-28NCT04958109
Frequently asked questions
Are there clinical trials for Kisspeptin?
Kisspeptin has 36 registered clinical trials, including 15 completed interventional studies and trials reaching Phase 3. Its use in humans is supported by established registered clinical evidence.
Does a registered trial mean the peptide works?
No. Registration means a study was formally listed before or during the research. It says nothing about the result. A completed trial can find no benefit, and many registered studies are never published.
What is the difference between a registered trial and published evidence?
Registration records that a study exists. Publication reports what it found. This page counts registrations, which is the more complete picture of research activity, but it is not a measure of proven effectiveness.
Why do phases matter?
Phase 1 tests safety in a small group. Phase 2 looks for early signs of effect. Phase 3 tests effectiveness against a comparator in a large group, and is what regulators normally require. Phase 4 studies happen after approval. A compound with only Phase 1 trials has not been shown to work.
Source: ClinicalTrials.gov API v2, U.S. National Library of Medicine. Studies where Kisspeptin is registered as an intervention. Last updated 2026-09-23.