Home / Clinical trials / LL-37
Are there clinical trials for LL-37?
LL-37 has 20 registered clinical trials reaching Phase 3, with 2 currently active, but 5 completed interventional studies so far.
Trial breakdown
By phase
| Phase 2 | 5 |
| Phase 1 | 3 |
| Not applicable | 2 |
| Early Phase 1 | 1 |
| Phase 3 | 1 |
By status
| Completed | 12 |
| Withdrawn | 3 |
| Unknown status | 2 |
| Recruiting | 1 |
| Terminated | 1 |
| Not yet recruiting | 1 |
Active trials
- Evaluation of 25(OH)D3 and LL-37 Levels in Periimplant Sulcus FluidNot yet recruiting · 72 participants · Recep Tayyip Erdogan University · started 2025-12-30NCT07280754
- Crosstalk Between Mucosal-Associated Invariant T (MAIT) Cells and the Gut Microbiota and Mucosa in the Development of Type 1 Diabetes in ChildrenRecruiting · 180 participants · Institut National de la Santé Et de la Recherche Médicale, France · started 2022-01-01NCT05054361
Most recent registered trials
- Evaluation of 25(OH)D3 and LL-37 Levels in Periimplant Sulcus FluidNot yet recruiting · 72 participants · Recep Tayyip Erdogan University · started 2025-12-30NCT07280754
- Cathelicidin LL-37 Relation to Potentially Malignant LesionsCompleted · 45 participants · Fayoum University · started 2023-07-01NCT06219330
- Crosstalk Between Mucosal-Associated Invariant T (MAIT) Cells and the Gut Microbiota and Mucosa in the Development of Type 1 Diabetes in ChildrenRecruiting · 180 participants · Institut National de la Santé Et de la Recherche Médicale, France · started 2022-01-01NCT05054361
- Chlorhexidine and Essential Oil Mouthwashes on Human Beta-Defensin 2 (hbD2) and Kathelicidin (LL-37) Saliva LevelsUnknown status · 120 participants · Istanbul Medeniyet University · started 2021-07-20NCT04946617
- The Role of Anti-inflammatory Cytokines and Antimicrobial Peptide LL-37 Biomarkers in the Treatment of Periodontal Disease.Completed · 60 participants · Universidad Rey Juan Carlos · started 2021-05-17NCT04404335
- Peri-implant Vitamin D and Cathelicidin (LL-37) LevelsCompleted · 33 participants · Altinbas University · started 2021-04-01NCT06867250
- Cathelicidin LL-37 Levels in the GCF and the Saliva of Smokers and Non-smokers With Stage III,IV PeriodontitisCompleted · 60 participants · Cairo University · started 2021-02-23NCT04861493
- Efficacy of LL-37 Cream on Bacteria Colonization, Inflammation Response and Healing Rate of Diabetic Foot UlcersPhase 2 · Unknown status · 40 participants · Fakultas Kedokteran Universitas Indonesia · started 2019-10NCT04098562
- Effect of High-Dose Vitamin D3 in Smokers and Non-Smokers With and Without HIVPhase 1 · Terminated · 7 participants · Emory University · started 2018-04-11NCT03270709
- Salivary TAS, TOS, LL-37 and Dental Status in Passive Smoking ChildrenCompleted · 180 participants · Merve Erkmen Almaz · started 2016-11-16NCT04292548
- Passive Smoking and LL-37 in ChildrenCompleted · 180 participants · Kırıkkale University · started 2016-11NCT03639376
- Evaluation of the Inhibitory Effects of Topical Ivermectin on Markers of Rosacea Specific Inflammation.Phase 1 / Phase 2 · Completed · 25 participants · University of California, San Diego · started 2016-07NCT02806414
Frequently asked questions
Are there clinical trials for LL-37?
LL-37 has 20 registered clinical trials reaching Phase 3, with 2 currently active, but 5 completed interventional studies so far.
Does a registered trial mean the peptide works?
No. Registration means a study was formally listed before or during the research. It says nothing about the result. A completed trial can find no benefit, and many registered studies are never published.
What is the difference between a registered trial and published evidence?
Registration records that a study exists. Publication reports what it found. This page counts registrations, which is the more complete picture of research activity, but it is not a measure of proven effectiveness.
Why do phases matter?
Phase 1 tests safety in a small group. Phase 2 looks for early signs of effect. Phase 3 tests effectiveness against a comparator in a large group, and is what regulators normally require. Phase 4 studies happen after approval. A compound with only Phase 1 trials has not been shown to work.
Source: ClinicalTrials.gov API v2, U.S. National Library of Medicine. Studies where LL-37 is registered as an intervention. Last updated 2026-09-23.