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Are there clinical trials for Follistatin?
Follistatin has 15 registered clinical trials, including 7 completed interventional studies and trials reaching Phase 4. Its use in humans is supported by established registered clinical evidence.
Trial breakdown
By phase
| Phase 1 | 4 |
| Phase 2 | 2 |
| Not applicable | 2 |
| Early Phase 1 | 1 |
| Phase 4 | 1 |
| Phase 3 | 1 |
By status
| Completed | 11 |
| Unknown status | 1 |
| Active, not recruiting | 1 |
| Not yet recruiting | 1 |
| Recruiting | 1 |
Active trials
- CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene TherapyPhase 1 / Phase 2 · Recruiting · 12 participants · Unlimited Biotechnology LLC · started 2026-06-01NCT07443826
- Effect of Acute Endurance Exercise on the Production of FGF21 and Follistatin in Patients With Hepatocellular CarcinomaNot applicable · Not yet recruiting · 12 participants · University Hospital, Clermont-Ferrand · started 2025-12NCT07189624
- Investigation of Possible Sarcopenia and/or the Presence of Sarcopenia in Patients With Primary Sjögren's Syndrome and Its Effect on Functional StatusActive, not recruiting · 120 participants · Antalya Training and Research Hospital · started 2025-07-20NCT07804719
Most recent registered trials
- CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene TherapyPhase 1 / Phase 2 · Recruiting · 12 participants · Unlimited Biotechnology LLC · started 2026-06-01NCT07443826
- Safety and Efficacy of Klotho and Follistatin Gene TherapyEarly Phase 1 · Completed · 14 participants · Minicircle · started 2025-12-16NCT07285629
- Effect of Acute Endurance Exercise on the Production of FGF21 and Follistatin in Patients With Hepatocellular CarcinomaNot applicable · Not yet recruiting · 12 participants · University Hospital, Clermont-Ferrand · started 2025-12NCT07189624
- Investigation of Possible Sarcopenia and/or the Presence of Sarcopenia in Patients With Primary Sjögren's Syndrome and Its Effect on Functional StatusActive, not recruiting · 120 participants · Antalya Training and Research Hospital · started 2025-07-20NCT07804719
- The Regulatory Role of miRNA 27 Follistatin Like Protein-1 Gene in Multiple ScelerosisUnknown status · 60 participants · Assiut University · started 2024-03NCT06290453
- Evaluation of Serum Follistatin-Like Protein 1 Levels in Behcet's Disease and Its Association With Disease ActivityCompleted · 80 participants · Assiut University · started 2024-01-01NCT06730958
- Phase I: Safety and Efficacy of an Injectable Follistatin Plasmid Gene Therapy in HumansPhase 1 · Completed · 43 participants · Minicircle · started 2022-08-18NCT06411366
- Follistatin Levels in Metabolically Healthy and Unhealthy Obese IndividualsCompleted · 62 participants · Goztepe Prof Dr Suleyman Yalcın City Hospital · started 2022-01-15NCT06229899
- Effect of 80-mg Atorvastatin on Myocardial EdemaPhase 3 · Completed · 40 participants · National Cardiovascular Center Harapan Kita Hospital Indonesia · started 2016-10NCT02901379
- Effect of L-arginine on Microcirculation, Myogenesis and Angiogenesis Associated With Aging, Sarcopenia and DiabetesNot applicable · Completed · 120 participants · Rio de Janeiro State University · started 2016-04NCT04112875
- Role of Myostatin, Activin A and Follistatin Cachexia of ENT CancersCompleted · 60 participants · University Hospital, Clermont-Ferrand · started 2015-11-02NCT03162042
- Clinical Intramuscular Gene Transfer of rAAV1.CMV.huFollistatin344 Trial to Patients With Duchenne Muscular DystrophyPhase 1 / Phase 2 · Completed · 3 participants · Jerry R. Mendell · started 2015-01NCT02354781
Frequently asked questions
Are there clinical trials for Follistatin?
Follistatin has 15 registered clinical trials, including 7 completed interventional studies and trials reaching Phase 4. Its use in humans is supported by established registered clinical evidence.
Does a registered trial mean the peptide works?
No. Registration means a study was formally listed before or during the research. It says nothing about the result. A completed trial can find no benefit, and many registered studies are never published.
What is the difference between a registered trial and published evidence?
Registration records that a study exists. Publication reports what it found. This page counts registrations, which is the more complete picture of research activity, but it is not a measure of proven effectiveness.
Why do phases matter?
Phase 1 tests safety in a small group. Phase 2 looks for early signs of effect. Phase 3 tests effectiveness against a comparator in a large group, and is what regulators normally require. Phase 4 studies happen after approval. A compound with only Phase 1 trials has not been shown to work.
Source: ClinicalTrials.gov API v2, U.S. National Library of Medicine. Studies where Follistatin is registered as an intervention. Last updated 2026-09-23.