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Are there clinical trials for Thymosin alpha-1?
Thymosin alpha-1 has 64 registered clinical trials, including 23 completed interventional studies and trials reaching Phase 4. Its use in humans is supported by established registered clinical evidence.
Trial breakdown
By phase
| Phase 2 | 32 |
| Phase 4 | 10 |
| Not applicable | 9 |
| Phase 3 | 8 |
| Phase 1 | 7 |
| Early Phase 1 | 1 |
By status
| Completed | 24 |
| Unknown status | 15 |
| Recruiting | 11 |
| Not yet recruiting | 6 |
| Withdrawn | 4 |
| Active, not recruiting | 2 |
| Enrolling by invitation | 1 |
| Terminated | 1 |
Active trials
- AI-assisted Subtyping-directed Precision Treatment in Acute Aortic DissectionNot applicable · Not yet recruiting · 300 participants · Nanjing Medical University · started 2027-12-31NCT07382375
- Study of Adebrelimab Combined With Thymalfasin and Chemotherapy for Neoadjuvant Treatment of Esophageal CancerPhase 2 · Not yet recruiting · 31 participants · The Affiliated Hospital of Putian University · started 2026-08-30NCT07780721
- Thymosin-α1 for Recurrent Implantation FailurePhase 2 / Phase 3 · Recruiting · 136 participants · Fakih IVF Fertility Center · started 2026-02-11NCT07675980
- A Study Evaluating Neoadjuvant Chemotherapy, Concurrent Chemoradiotherapy Combined With Dual Immune Checkpoint Blockade in Patients With Locally Advanced Non-Small Cell Lung CancerPhase 2 · Recruiting · 56 participants · Sun Yat-sen University · started 2026-01-01NCT07103395
- Phase II Trial of Neoadjuvant Thymalfasin, PD-1 Inhibitor, and Chemoradiotherapy for cStage III GEJ AdenocarcinomaPhase 2 · Recruiting · 48 participants · The First Affiliated Hospital with Nanjing Medical University · started 2025-12-16NCT07277439
- A Study Evaluating Concurrent Chemoradiotherapy Combined With Dual Immune Checkpoint Blockade for Limited-stage Small Cell Lung CancerPhase 2 · Not yet recruiting · 56 participants · Sun Yat-sen University · started 2025-10-01NCT07103408
- Protective Effect of Ulinastatin and Thymosin α1 Against Negative Immune Dysregulation and Organ Dysfunction After Acute Aortic Dissection Surgery (PANDA XI)Not applicable · Enrolling by invitation · 200 participants · Nanjing Medical University · started 2025-04-01NCT06966687
- "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer"Phase 2 · Recruiting · 52 participants · Beijing Friendship Hospital · started 2025-02-11NCT06829355
Most recent registered trials
- AI-assisted Subtyping-directed Precision Treatment in Acute Aortic DissectionNot applicable · Not yet recruiting · 300 participants · Nanjing Medical University · started 2027-12-31NCT07382375
- Study of Adebrelimab Combined With Thymalfasin and Chemotherapy for Neoadjuvant Treatment of Esophageal CancerPhase 2 · Not yet recruiting · 31 participants · The Affiliated Hospital of Putian University · started 2026-08-30NCT07780721
- Thymosin-α1 for Recurrent Implantation FailurePhase 2 / Phase 3 · Recruiting · 136 participants · Fakih IVF Fertility Center · started 2026-02-11NCT07675980
- A Study Evaluating Neoadjuvant Chemotherapy, Concurrent Chemoradiotherapy Combined With Dual Immune Checkpoint Blockade in Patients With Locally Advanced Non-Small Cell Lung CancerPhase 2 · Recruiting · 56 participants · Sun Yat-sen University · started 2026-01-01NCT07103395
- Phase II Trial of Neoadjuvant Thymalfasin, PD-1 Inhibitor, and Chemoradiotherapy for cStage III GEJ AdenocarcinomaPhase 2 · Recruiting · 48 participants · The First Affiliated Hospital with Nanjing Medical University · started 2025-12-16NCT07277439
- A Study Evaluating Concurrent Chemoradiotherapy Combined With Dual Immune Checkpoint Blockade for Limited-stage Small Cell Lung CancerPhase 2 · Not yet recruiting · 56 participants · Sun Yat-sen University · started 2025-10-01NCT07103408
- Protective Effect of Ulinastatin and Thymosin α1 Against Negative Immune Dysregulation and Organ Dysfunction After Acute Aortic Dissection Surgery (PANDA XI)Not applicable · Enrolling by invitation · 200 participants · Nanjing Medical University · started 2025-04-01NCT06966687
- "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer"Phase 2 · Recruiting · 52 participants · Beijing Friendship Hospital · started 2025-02-11NCT06829355
- Thymalfasin (Thymosin Alpha 1; Ta1) as an Enhancer of Vaccine Response Among Older Adults Receiving Booster Doses of COVID-19 VaccinePhase 1 · Recruiting · 75 participants · The Methodist Hospital Research Institute · started 2024-12-02NCT06821100
- Neoadjuvant With Tα1 Plus Immuno-chemotherapy for Resectable NSCLCNot applicable · Not yet recruiting · 40 participants · Xuanwu Hospital, Beijing · started 2024-10-15NCT06607926
- Thymalfasin and Recombinant Human IL-2 Injections in Treating Lymphocytopenia for Patients With Malignant Hematological TumorsPhase 2 · Recruiting · 50 participants · The First Affiliated Hospital of Xiamen University · started 2024-09-01NCT06584006
- Radiotherapy With Sequential Chemotherapy Combined With PD-1 Inhibitor and Thymalfasin for BRPCPhase 2 · Not yet recruiting · 20 participants · Ruijin Hospital · started 2024-09-01NCT06573398
Frequently asked questions
Are there clinical trials for Thymosin alpha-1?
Thymosin alpha-1 has 64 registered clinical trials, including 23 completed interventional studies and trials reaching Phase 4. Its use in humans is supported by established registered clinical evidence.
Does a registered trial mean the peptide works?
No. Registration means a study was formally listed before or during the research. It says nothing about the result. A completed trial can find no benefit, and many registered studies are never published.
What is the difference between a registered trial and published evidence?
Registration records that a study exists. Publication reports what it found. This page counts registrations, which is the more complete picture of research activity, but it is not a measure of proven effectiveness.
Why do phases matter?
Phase 1 tests safety in a small group. Phase 2 looks for early signs of effect. Phase 3 tests effectiveness against a comparator in a large group, and is what regulators normally require. Phase 4 studies happen after approval. A compound with only Phase 1 trials has not been shown to work.
Source: ClinicalTrials.gov API v2, U.S. National Library of Medicine. Studies where Thymosin alpha-1 is registered as an intervention. Last updated 2026-09-23.