Home / Clinical trials / Bivalirudin
Are there clinical trials for Bivalirudin?
Bivalirudin has 92 registered clinical trials, including 38 completed interventional studies and trials reaching Phase 4. Its use in humans is supported by established registered clinical evidence.
Trial breakdown
By phase
| Phase 4 | 39 |
| Phase 3 | 23 |
| Not applicable | 11 |
| Phase 2 | 7 |
| Phase 1 | 3 |
By status
| Completed | 42 |
| Unknown status | 29 |
| Terminated | 8 |
| Recruiting | 6 |
| Withdrawn | 4 |
| Not yet recruiting | 2 |
| Active, not recruiting | 1 |
Active trials
- Bivalirudin Versus Heparin During PCI in High Bleeding Risk Patients With Acute Coronary SyndromesPhase 4 · Not yet recruiting · 5270 participants · Shenyang Northern Hospital · started 2026-02-01NCT07383155
- Bivalirudin with Prolonged Infusion During PCI Versus Heparin After Fibrinolytic TherapyNot applicable · Not yet recruiting · 2400 participants · First Affiliated Hospital Xi'an Jiaotong University · started 2025-05NCT06861374
- Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp SystemPhase 2 · Recruiting · 50 participants · Stanford University · started 2025-04-15NCT06080074
- Use of Bivalirudin for Anticoagulation in Patients With Extracorporeal Membrane OxygenationNot applicable · Recruiting · 154 participants · Xiaotong Hou · started 2024-06-03NCT06275555
- BivaLirudin versUS Heparin in Extracorporeal Membrane OxygenationPhase 2 · Recruiting · 80 participants · Sydney Local Health District · started 2024-05-01NCT05959252
- A Study on the Impact of Bivalirudin Usage During PCI for High-risk Plaques on Post-PCI Coronary Microcirculation.Phase 4 · Recruiting · 70 participants · Peking University First Hospital · started 2023-07-01NCT05984537
- Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)Recruiting · 5000 participants · Duke University · started 2020-03-05NCT04278404
- Pharmacokinetics of Bivalirudin for Pediatric AnticoagulationRecruiting · 30 participants · Boston Children's Hospital · started 2018-07-12NCT03532399
Most recent registered trials
- Bivalirudin Versus Heparin During PCI in High Bleeding Risk Patients With Acute Coronary SyndromesPhase 4 · Not yet recruiting · 5270 participants · Shenyang Northern Hospital · started 2026-02-01NCT07383155
- Bivalirudin with Prolonged Infusion During PCI Versus Heparin After Fibrinolytic TherapyNot applicable · Not yet recruiting · 2400 participants · First Affiliated Hospital Xi'an Jiaotong University · started 2025-05NCT06861374
- Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp SystemPhase 2 · Recruiting · 50 participants · Stanford University · started 2025-04-15NCT06080074
- Use of Bivalirudin for Anticoagulation in Patients With Extracorporeal Membrane OxygenationNot applicable · Recruiting · 154 participants · Xiaotong Hou · started 2024-06-03NCT06275555
- BivaLirudin versUS Heparin in Extracorporeal Membrane OxygenationPhase 2 · Recruiting · 80 participants · Sydney Local Health District · started 2024-05-01NCT05959252
- A Study on the Impact of Bivalirudin Usage During PCI for High-risk Plaques on Post-PCI Coronary Microcirculation.Phase 4 · Recruiting · 70 participants · Peking University First Hospital · started 2023-07-01NCT05984537
- Bivalirudin Versus Enoxaparin in Critically Ill COVID-19 PatientsNot applicable · Completed · 58 participants · University Magna Graecia · started 2022-04-20NCT05334654
- Bivalirudin vs Heparin in ECMO PatientsPhase 1 · Withdrawn · Johns Hopkins University · started 2021-04NCT03707418
- Safety and Efficacy of Bivalirudin During Short-term Intervention of Non-infarction Related Artery After PPCI of STEMINot applicable · Unknown status · 100 participants · First Affiliated Hospital Xi'an Jiaotong University · started 2021-01-12NCT04475835
- Efficacy and Safety of Bivalirudin Versus Heparin During Coil Embolization in Patients With Ruptured Intracranial AneurysmsPhase 3 · Unknown status · 236 participants · Changhai Hospital · started 2020-08NCT04532333
- Anticoagulation in Patients Suffering From COVID-19 Disease The ANTI-CO TrialPhase 4 · Unknown status · 100 participants · Hamad Medical Corporation · started 2020-06-28NCT04445935
- Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)Recruiting · 5000 participants · Duke University · started 2020-03-05NCT04278404
Frequently asked questions
Are there clinical trials for Bivalirudin?
Bivalirudin has 92 registered clinical trials, including 38 completed interventional studies and trials reaching Phase 4. Its use in humans is supported by established registered clinical evidence.
Does a registered trial mean the peptide works?
No. Registration means a study was formally listed before or during the research. It says nothing about the result. A completed trial can find no benefit, and many registered studies are never published.
What is the difference between a registered trial and published evidence?
Registration records that a study exists. Publication reports what it found. This page counts registrations, which is the more complete picture of research activity, but it is not a measure of proven effectiveness.
Why do phases matter?
Phase 1 tests safety in a small group. Phase 2 looks for early signs of effect. Phase 3 tests effectiveness against a comparator in a large group, and is what regulators normally require. Phase 4 studies happen after approval. A compound with only Phase 1 trials has not been shown to work.
Source: ClinicalTrials.gov API v2, U.S. National Library of Medicine. Studies where Bivalirudin is registered as an intervention. Last updated 2026-09-23.