Home / Clinical trials / Tirzepatide
Are there clinical trials for Tirzepatide?
Tirzepatide has 296 registered clinical trials, including 75 completed interventional studies and trials reaching Phase 4. Its use in humans is supported by established registered clinical evidence.
Trial breakdown
By phase
| Phase 2 | 77 |
| Phase 3 | 57 |
| Phase 4 | 48 |
| Phase 1 | 39 |
| Not applicable | 27 |
| Early Phase 1 | 6 |
By status
| Recruiting | 98 |
| Completed | 91 |
| Not yet recruiting | 62 |
| Active, not recruiting | 31 |
| Enrolling by invitation | 5 |
| Withdrawn | 4 |
| Unknown status | 4 |
| Terminated | 1 |
Active trials
- Tirzepatide for the Treatment of Cannabis Use DisorderPhase 2 · Not yet recruiting · 6 participants · Brigham and Women's Hospital · started 2027-03-01NCT07265752
- Effects of Tirzepatide on Gut Microbiota and Gastrointestinal Function After Drug Withdrawal in Obese PatientsNot yet recruiting · 80 participants · Nanjing First Hospital, Nanjing Medical University · started 2027-02-01NCT07847515
- GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF RegistryNot yet recruiting · 150 participants · Miedziowe Centrum Zdrowia SA · started 2027-01-01NCT07787936
- Preoperative Optimization With Tirzepatide, Ketogenic Diet, or Standard Care Before One Anastomosis Gastric Bypass SurgeryNot yet recruiting · 96 participants · Mario Musella MD · started 2027-01-01NCT07622992
- Efficacy of Tirzepatide for Weight Management in Patients With Suboptimal Weight Loss After Bariatric Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical TrialPhase 3 · Not yet recruiting · 70 participants · Universidade do Porto · started 2027-01NCT07829198
- Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial CancerPhase 2 · Not yet recruiting · 40 participants · UNC Lineberger Comprehensive Cancer Center · started 2027-01NCT07078838
- Tirzepatide for the Treatment of Concurrent Type 1 Diabetes and Overweight or ObesityPhase 2 · Not yet recruiting · 40 participants · Royal North Shore Hospital · started 2026-12NCT06180616
- Trial of Tirzepatide for the Treatment of Cannabis Use DisorderPhase 2 · Not yet recruiting · 100 participants · National Institute on Drug Abuse (NIDA) · started 2026-11-15NCT07468552
Most recent registered trials
- Tirzepatide for the Treatment of Cannabis Use DisorderPhase 2 · Not yet recruiting · 6 participants · Brigham and Women's Hospital · started 2027-03-01NCT07265752
- Effects of Tirzepatide on Gut Microbiota and Gastrointestinal Function After Drug Withdrawal in Obese PatientsNot yet recruiting · 80 participants · Nanjing First Hospital, Nanjing Medical University · started 2027-02-01NCT07847515
- GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF RegistryNot yet recruiting · 150 participants · Miedziowe Centrum Zdrowia SA · started 2027-01-01NCT07787936
- Preoperative Optimization With Tirzepatide, Ketogenic Diet, or Standard Care Before One Anastomosis Gastric Bypass SurgeryNot yet recruiting · 96 participants · Mario Musella MD · started 2027-01-01NCT07622992
- Efficacy of Tirzepatide for Weight Management in Patients With Suboptimal Weight Loss After Bariatric Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical TrialPhase 3 · Not yet recruiting · 70 participants · Universidade do Porto · started 2027-01NCT07829198
- Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial CancerPhase 2 · Not yet recruiting · 40 participants · UNC Lineberger Comprehensive Cancer Center · started 2027-01NCT07078838
- Tirzepatide for the Treatment of Concurrent Type 1 Diabetes and Overweight or ObesityPhase 2 · Not yet recruiting · 40 participants · Royal North Shore Hospital · started 2026-12NCT06180616
- Trial of Tirzepatide for the Treatment of Cannabis Use DisorderPhase 2 · Not yet recruiting · 100 participants · National Institute on Drug Abuse (NIDA) · started 2026-11-15NCT07468552
- SYNCHRONIZE®-START- A Study to Test Whether Survodutide Helps People Living With Overweight or Obesity Who do Not Have Diabetes to Lose WeightPhase 3 · Not yet recruiting · 350 participants · Boehringer Ingelheim · started 2026-11-07NCT07855900
- A Study of SYH2069 Injection in Participants With T2DM Not Controlled With Diet/Exercise Alone or MetforminPhase 2 · Not yet recruiting · 240 participants · CSPC Ouyi Pharmaceutical Co., Ltd. · started 2026-11-06NCT07796477
- Comparing Different Medication Regimens to Maintaining Weight Loss Among Adults With Obesity Using GLP-1sPhase 4 · Not yet recruiting · 60 participants · Jing Luo · started 2026-11-01NCT07832084
- A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial CancerPhase 2 · Not yet recruiting · 55 participants · National Cancer Institute (NCI) · started 2026-11-01NCT07349641
Frequently asked questions
Are there clinical trials for Tirzepatide?
Tirzepatide has 296 registered clinical trials, including 75 completed interventional studies and trials reaching Phase 4. Its use in humans is supported by established registered clinical evidence.
Does a registered trial mean the peptide works?
No. Registration means a study was formally listed before or during the research. It says nothing about the result. A completed trial can find no benefit, and many registered studies are never published.
What is the difference between a registered trial and published evidence?
Registration records that a study exists. Publication reports what it found. This page counts registrations, which is the more complete picture of research activity, but it is not a measure of proven effectiveness.
Why do phases matter?
Phase 1 tests safety in a small group. Phase 2 looks for early signs of effect. Phase 3 tests effectiveness against a comparator in a large group, and is what regulators normally require. Phase 4 studies happen after approval. A compound with only Phase 1 trials has not been shown to work.
Source: ClinicalTrials.gov API v2, U.S. National Library of Medicine. Studies where Tirzepatide is registered as an intervention. Last updated 2026-10-05.
